Qalabka ELISA ee Kahortagga-Cyclic Citrullinated Peptide (CCP).

Qalabka Kahortagga Baaskiilada Citrullinated Peptide (CCP) Kahortagga Jirka ELISA Qalabka Sawirka leh

Sharaxaad Gaaban:

Alaabtan waxaa loogu talagalay in lagu ogaado tayada in vitro ee heerarka anti-cyclic citrullinated peptide antibody ee serum aadanaha. Kiliinik ahaan, waxa loo adeegsan karaa sidii qalab lagu baadho kaaliyaha ee rheumatoid arthritis-ka (RA).

Unugyada difaaca jirka ee citrullinated peptide waa autoantibodies kuwaas oo bartilmaameedsada peptides citrullinated cyclic, oo ah nooc ka mid ah antigen-ka borotiinka ee la beddelay. Joogitaankooda waxay si dhow ula xiriiraan rheumatoid arthritis-ka, cudur dabadheeraad ah oo difaaca jirka oo lagu garto caabuqa wadajirka ah iyo dhaawaca. Marka la barbardhigo calaamadaha kale ee rheumatoid-ka, unugyada difaaca jirka waxay muujinayaan sifooyin sare oo loogu talagalay RA, gaar ahaan marxaladaha hore ee cudurka marka calaamadaha bukaan-socodka aysan weli caadi ahayn.

Bukaannada laga shakisan yahay RA, ogaanshaha heerarka anti-cyclic citrullinated peptide antibody waxay gacan ka geysan kartaa xaqiijinta ogaanshaha marxaladda hore, taas oo muhiim u ah faragelinta waqtiga iyo ka hortagga burburka wadajirka ah ee aan laga laaban karin. Waxa kale oo ay gacan ka geysataa kala soocida RA ee noocyada kale ee arthritis-ka ee leh calaamado isku mid ah, taas oo ku hagaya daaweeyayaasha si ay u horumariyaan qorshooyin daaweyn oo badan oo la beegsanayo iyo hagaajinta maareynta guud ee cudurka.

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Mabda'a

Xirmadani waxay ogaataa anti-cyclic citrullinated peptide antibodies (CCP antibodies) ee muunadaha serum ee bini'aadamka ee ku salaysan habka aan tooska ahayn, iyada oo la safeeyey peptide antigens cyclic citrullinated peptide antigens oo loo isticmaalo sidii antigen-ka dahaarka.

Habka shaybaadhku waxa uu ka bilaabmayaa in lagu daro muunada serumka ee ceelasha falcelinta ee hore loogu dahaadhay antigens-ka la safeeyey ee aan soo sheegnay, oo ay ku xigto muddada soo saarista. Inta lagu jiro soo-saarkan, haddii unugyada difaaca jirka ee CCP ay ku jiraan muunada, waxay si gaar ah u aqoonsan doonaan oo ay ku xidhi doonaan antigens-ka citrullinated ee peptide-ka ee ku dahaaran microwells, samaynta dhismayaal antigen-antibody deggan. Si loo hubiyo saxnaanta tillaabooyinka xiga, qaybaha aan xidhnayn ee ceelasha falcelinta ayaa laga saarayaa habka dhaqidda, kaas oo gacan ka geysta baabi'inta faragelinta suurtagalka ah ee walxaha kale ee serumka.

Marka xigta, isku-xireyaasha enzymes ayaa lagu daraa ceelasha falcelinta. Ka dib markii labaad, kuwan enzyme conjugates waxay si gaar ah ugu dhejin doonaan dhismooyinka antigen-antibody ee jira, samaynta isku-dhafan difaac weyn oo ay ku jiraan antigen, antibody, iyo enzyme conjugate. Marka xalka TMB substrate la soo geliyo nidaamka, enzyme-ka ku jira conjugate wuxuu kiciyaa falcelinta kiimikaad ee substrate-ka TMB, taasoo keentay isbeddel midab muuqda. Xoogagga falcelinta midabkani waxay si toos ah ula xiriirtaa cadadka unugyada difaaca CCP ee ku jira muunadda serum-ka asalka ah. Ugu dambeyntii, akhristaha microplate ayaa loo isticmaalaa si loo cabbiro nuugista (qiimaha A) ee isku dhafka falcelinta. Marka la falanqeeyo qiimaha nuugista, heerka unugyada difaaca jirka ee CCP ee muunada ayaa si sax ah loo go'aamin karaa, iyadoo siinaya saldhig la isku halayn karo oo ku saabsan baaritaanka iyo ogaanshaha caafimaad ee khuseeya.

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Mabda'a	Baaritaanka difaaca jirka ee Enzyme ayaa ku xiran
Nooca	DadbanHabka
Shahaado	NMPA
Tijaabada	Serum / plasma
Tilmaamid	48T /96T
Heerkulka kaydinta	2-8℃
Nolosha shelf	12bilo